GPT-Rosalind (OpenAI)
C Tier · 6.8/10
OpenAI's first domain-specific model -- life sciences, drug discovery, translational medicine. Launched 2026-04-16 as a Trusted Access research preview. Launch partners: Amgen, Moderna, Allen Institute, Thermo Fisher. Paired with a Life Sciences Codex plugin (50+ scientific tool integrations)
Score Breakdown
The Good and the Bad
What we like
- +OpenAI's first named vertical/domain-specific model -- signals a new strategy beyond general-purpose GPT-5.x. The pattern (vertical + gated rollout + blue-chip launch partners) echoes the 2026-04-07 Anthropic Mythos Preview / Project Glasswing model and suggests how frontier-lab productization will work in 2026 and beyond
- +Launch partners Amgen, Moderna, Allen Institute, Thermo Fisher are credible biotech and research institutions -- not just splashy logos. Suggests the model has been meaningfully trained/tuned on real biology data with real domain expertise in the loop
- +Life Sciences Codex plugin is the practical hook -- 50+ scientific tool integrations (PubMed, BioRxiv, UniProt, scientific Python libraries) mean Codex can now run multi-step research workflows: literature search, protein lookup, reagent ordering scripts, experimental design in one chain
- +OpenAI is now playing in the space Anthropic's Mythos targets (gated domain models) with Nvidia's vertical strategy (BioNeMo, Evo) and Google's Med-PaLM lineage. Competition drives rapid improvement
What could be better
- −Not available to anyone reading this unless your org is already a Trusted Access partner. If you are at Amgen or Moderna, ask internally. Everyone else: wait and see
- −Domain-specific model, so for general-purpose work Opus 4.7, GPT-5.4, or Gemini 3.1 Pro remain the right answer -- GPT-Rosalind will be narrower in scope even once broadly available
- −Trusted Access means OpenAI controls who uses it. Unlike consumer ChatGPT, there is no path from 'I am curious' to 'I am using it' without an enterprise sales conversation
- −Claims need third-party verification. At launch, OpenAI has not published open benchmarks. Expect published drug-discovery / biology evals from neutral sources over next 3-6 months
Pricing
Trusted Access (gated)
- ✓Research preview limited to partner organizations
- ✓Launch partners: Amgen, Moderna, Allen Institute for Cell Science, Thermo Fisher
- ✓Application required via OpenAI enterprise sales
- ✓Not available to consumer ChatGPT users
Life Sciences Codex Plugin
- ✓50+ scientific tool integrations (PubMed, BioRxiv, UniProt, etc.)
- ✓Works with Codex cloud agent for multi-step research workflows
- ✓Available in ChatGPT Pro ($100/mo) and Business tiers
Public access
- ✓Not being released publicly as a standalone product
- ✓Consumer use case unclear -- this is an enterprise / research tool
Known Issues
- Trusted Access rollout -- not open for self-serve signup. Launched 2026-04-16 with fewer than 10 named partners. Broader access timeline not announcedSource: OpenAI launch post · 2026-04
- No independently-published benchmark results yet. OpenAI's claims (life-science reasoning superiority over general-purpose GPT-5.x) rely on internal evaluations. Wait for neutral published comparisons over Q2/Q3 2026Source: VentureBeat, OpenAI launch coverage · 2026-04
Best for
Researchers and enterprises in biology, drug discovery, protein science, translational medicine, or adjacent life-sciences domains who can get Trusted Access. Also relevant to anyone building life-sciences AI products who needs to understand where OpenAI's vertical strategy is heading.
Not for
General-purpose use (use GPT-5.4, Opus 4.7, or Gemini 3.1 Pro). Consumer users who are not in a partner org (no access available). Anyone expecting standalone consumer pricing -- this is an enterprise / research play only.
Our Verdict
GPT-Rosalind is OpenAI's first named vertical model, launched 2026-04-16 as a Trusted Access preview with Amgen, Moderna, Allen Institute, and Thermo Fisher as launch partners. The parallel to Anthropic's Mythos Preview (2026-04-07) is clear: frontier labs are shipping gated domain-specific models while keeping their general-purpose models (GPT-5.x, Opus 4.x) publicly accessible. For life-sciences researchers in those partner orgs, this is a real capability upgrade worth exploring. For everyone else, it is a strategic signal: expect GPT-[domain] models in law, finance, defense, and other verticals through 2026, and expect broad availability never to materialize for the most capable tiers. The bundled Life Sciences Codex plugin (50+ scientific tool integrations) is the more immediately actionable item -- ChatGPT Pro and Business users can run multi-step life-sciences research workflows with it starting today.
Sources
- OpenAI: Introducing GPT-Rosalind (accessed 2026-04-17)
- VentureBeat: OpenAI debuts GPT-Rosalind + Codex plugin (accessed 2026-04-17)
- Industry analysis of vertical AI strategy (accessed 2026-04-17)
Explore more GPT-Rosalind (OpenAI) rankings
Deeper leaderboards, benchmarks, task-specific tier lists, and status/pricing pages for GPT-Rosalind (OpenAI).
The Tier List Tuesday
Weekly newsletter: tier movers, new entrants, and the VS of the week. Built from our daily AI-tool sweeps. No spam, unsubscribe anytime.
Alternatives to GPT-Rosalind (OpenAI)
Claude (Anthropic)
Anthropic's flagship LLM family. **Claude Opus 5 launched 2026-07-24** and is now the default model on Claude Max and the strongest model on Claude Pro -- same $5/$25 per 1M as Opus 4.8, but Anthropic says it lands within 0.5% of Fable 5 on CursorBench at half the cost. **Sonnet 5's $2/$10 per 1M is now permanent** -- Anthropic cancelled the 2026-09-01 rise to $3/$15 and made the launch rate standard -- and it stays the default on Free/Pro. **Claude Fable 5.1 and Mythos 5.1 launched 2026-09-01** and now top the range -- same $10/$50 per 1M as Fable 5, with the saving delivered entirely through a 4x cheaper cache read ($1 -> $0.25/MTok), so it is 25-45% cheaper only if your workload reuses cached context. **From 2026-08-14 future Claude models watermark their text output globally** (SynthID-Text; no extra tokens, no price or speed change, no identifying information -- detector API not shipped yet), and the **legacy Workbench plus the experimental prompt-tools APIs retired 2026-08-17**
Claude Mythos 5.1
Anthropic's trusted-access frontier model. **Mythos 5.1 launched 2026-09-01** alongside Fable 5.1, and Anthropic now states outright that they are **the same model with different safeguards** -- the 5.1-cycle gap is 60.9% vs 55.8% on Terminal-Bench 4.0, which Anthropic attributes to safeguard interventions rather than capability and expects to shrink. Originally launched June 9, 2026 alongside Claude Fable 5. Suspended June 12 by a US export-control order, then PARTIALLY RESTORED July 1, 2026 (US government lifted controls June 30): Mythos 5 is back for a set of US organizations with government approval, while Anthropic works to re-expand the broader Glasswing program. Public Fable 5 returned globally the same day. Gated to Project Glasswing orgs + select biology researchers.
Gemini (Google)
Google's LLM with deep Google Workspace integration, 2M token context window, and native code execution -- **Gemini 3.8 Flash launched 2026-09-02** -- the third Flash release in six weeks -- at the SAME $0.75/$3.75 per 1M intro rate as 3.7 Flash and, critically, **on the same 2026-12-31 expiry** (then $1.50/$7.50), so the discount window did not reset. HLE-Verified 54.9%; Google warns it uses more tokens per task because it 'works harder', so cost per task can rise at an unchanged rate. **Gemini 3.8 Flash Cyber** is trusted-defenders-only via the new **Fairwind Program**. Gemini 3.7 Flash (2026-08-13) remains fully supported for efficiency-first work. Gemini 3.5 Pro STILL delayed and partner-testing-only (Bloomberg, 7/16 -- coding shortfalls, no ship date), so Flash keeps shipping while the Pro line stalls. Gemini 4 pre-training underway. **Two new models in Aug 2026: Gemini 3.5 Transcribe (2026-08-26) speech-to-text and Gemini Omni 1.1 Flash (2026-08-27) production video with 40s scene extension, start/end frames and 4K** -- neither shipped with a public rate card
Grok
SpaceXAI's irreverent chatbot with a direct line to X/Twitter -- and now **Grok 4.6 (launched 2026-08-12)**, focused on long-running agents and interactive/visual work, at the same $2/$6 per 1M as Grok 4.5 (fast variant 2x). xAI says it matches GPT-5.6 Sol on the AA Intelligence Index (61), though Sol still leads it on DeepSWE and Terminal-Bench. **Grok Bot** (8/11, early beta) adds always-on agents with their own cloud computer. **Grok 4.6 reached GitHub Copilot on 2026-08-14** across all five paid Copilot SKUs (off by default for orgs), adding to its day-one Cursor availability. Grok 4.3 remains the value tier at $1.25/$2.50
Muse Spark (Meta)
Meta's frontier model line from its Superintelligence Lab -- Muse Spark 1.1 (2026-07-09) adds substantially better coding, 1M-token multi-agent orchestration, and Meta's first paid developer API (Meta Model API, public preview)
GPT-5.4-Cyber (OpenAI)
OpenAI's defensive-cybersecurity variant of GPT-5.4, launched 2026-04-16. Lowered refusal boundary for security-research tasks and native binary reverse-engineering. Access gated via Trusted Access for Cyber (TAC) program -- thousands of verified defenders, hundreds of teams, no public pricing. On **2026-08-17 OpenAI published its first dedicated post on the Hugging Face incident**, conceding it 'underestimated the real-world cyber capabilities of our AI models' and confirming it now releases cyber capabilities only to trusted defenders. **On 2026-09-01 OpenAI confirmed GPT-6 Astra meets the Critical cyber threshold -- the first model it has ever designated at that level -- and on 2026-09-03 committed $1B to Daybreak for Frontline Defenders**
Microsoft MAI-Thinking-1
Microsoft's first in-house reasoning model -- launched 2026-06-02 at Build as the flagship of seven new MAI models. 35B-active / ~1T-total sparse Mixture-of-Experts, 256K context. AIME 2025 97.0%, matches leading models on SWE-Bench Pro, and beat Claude Sonnet 4.6 in human-preference testing. Available on Microsoft Foundry + OpenRouter / Fireworks / Baseten
Hunyuan 3 (Tencent Hy3)
Tencent's Hy3 reached GA 2026-07-06 (upgraded from the April preview) -- 295B total / 21B active MoE, 256K context, now Apache 2.0 open weights on HuggingFace + ModelScope with the EU/UK/South Korea restriction lifted. ~90% agent-task completion on Tencent's internal apps; API via Tencent Cloud TokenHub. Integrated into Yuanbao, WeChat, QQ
MiMo (Xiaomi)
Xiaomi's MiMo-V2.5 family launched 2026-04-22 -- Pro (1T total / 42B active MoE, 1M context, native vision+audio reasoning), Multimodal base, TTS (3 sub-models: base, VoiceDesign, VoiceClone), and ASR (open-source, English + Chinese + major dialects). Full voice pipeline for the agent era. Extra-charge 1M-context tier removed at launch